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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK10 All Species: 22.12
Human Site: T133 Identified Species: 40.56
UniProt: Q15131 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15131 NP_001092003.2 360 41038 T133 S L L E N M P T P F S E A Q V
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_546775 360 41038 T133 S L L E N M P T P F S E A Q V
Cat Felis silvestris
Mouse Mus musculus Q3UMM4 360 40942 T133 S L L E N M P T P F S E A Q V
Rat Rattus norvegicus Q4KM47 358 40615 T131 S L L E N M P T P F S E A Q V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001103409 370 41951 T141 S L L E N M Q T P F S E A Q V
Frog Xenopus laevis P23437 297 33852 E81 N K L Y L V F E F L N Q D L K
Zebra Danio Brachydanio rerio NP_001017622 275 30997 D59 G I V Y R A R D T R T N E I V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VPC0 952 108820 N652 S L M E T M K N R K Q S F F P
Honey Bee Apis mellifera XP_392973 410 46389 A159 S L L D N M Q A P F S E S Q V
Nematode Worm Caenorhab. elegans Q09437 719 83549 R451 S L L D T M S R R N K R F S I
Sea Urchin Strong. purpuratus XP_783449 397 44907 S153 S L L D N M P S P F T E T Q V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LFT8 505 56711 L134 G L A D R P G L R F T V P Q I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q871M9 545 61347 V127 G L L D N P S V R F T E P Q V
Conservation
Percent
Protein Identity: 100 N.A. N.A. 93 N.A. 96.9 90.5 N.A. N.A. 82.9 36.9 60.8 N.A. 21.3 63.9 25.8 63.7
Protein Similarity: 100 N.A. N.A. 96.9 N.A. 98.8 93.6 N.A. N.A. 89.7 53.6 69.1 N.A. 27.8 73.6 36.4 75.8
P-Site Identity: 100 N.A. N.A. 100 N.A. 100 100 N.A. N.A. 93.3 6.6 6.6 N.A. 26.6 73.3 26.6 73.3
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 100 N.A. N.A. 93.3 33.3 26.6 N.A. 33.3 86.6 40 93.3
Percent
Protein Identity: N.A. N.A. N.A. 31.4 N.A. 29.7
Protein Similarity: N.A. N.A. N.A. 45.5 N.A. 43.6
P-Site Identity: N.A. N.A. N.A. 20 N.A. 46.6
P-Site Similarity: N.A. N.A. N.A. 40 N.A. 60
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 8 0 8 0 0 0 0 39 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 39 0 0 0 8 0 0 0 0 8 0 0 % D
% Glu: 0 0 0 47 0 0 0 8 0 0 0 62 8 0 0 % E
% Phe: 0 0 0 0 0 0 8 0 8 70 0 0 16 8 0 % F
% Gly: 24 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 0 0 0 8 16 % I
% Lys: 0 8 0 0 0 0 8 0 0 8 8 0 0 0 8 % K
% Leu: 0 85 77 0 8 0 0 8 0 8 0 0 0 8 0 % L
% Met: 0 0 8 0 0 70 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 62 0 0 8 0 8 8 8 0 0 0 % N
% Pro: 0 0 0 0 0 16 39 0 54 0 0 0 16 0 8 % P
% Gln: 0 0 0 0 0 0 16 0 0 0 8 8 0 70 0 % Q
% Arg: 0 0 0 0 16 0 8 8 31 8 0 8 0 0 0 % R
% Ser: 70 0 0 0 0 0 16 8 0 0 47 8 8 8 0 % S
% Thr: 0 0 0 0 16 0 0 39 8 0 31 0 8 0 0 % T
% Val: 0 0 8 0 0 8 0 8 0 0 0 8 0 0 70 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 16 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _